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Symbol
Name
ID

Lyst
lysosomal trafficking regulator
MGI:107448

Phenotype annotations related to immune system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal leukocyte morphology

Neutropenia

Leukopenia

Abnormal natural killer cell morphology

Vacuolated lymphocytes

Increased proportion of CD25+ mast cells

Giant neutrophil granules

Abnormality of neutrophil physiology

Impaired neutrophil bactericidal activity

Hemophagocytosis

Periodontitis

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Recurrent bacterial skin infections

Skin rash

Immunodeficiency

Recurrent infections

Recurrent bacterial infections

Recurrent staphylococcal infections

Recurrent streptococcal infections

Recurrent systemic pyogenic infections

Recurrent respiratory infections

Disease(s) Associated with LYST

Chediak-Higashi syndrome

Mouse Phenotypes

impaired macrophage phagocytosis

abnormal eosinophil morphology

abnormal granulocyte morphology

abnormal dermal mast cell morphology

abnormal neutrophil morphology

absent NK T cells

decreased macrophage cell number

abnormal lymphocyte morphology

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

decreased cytotoxic T cell cytolysis

alveolitis

abnormal susceptibility to infection

increased susceptibility to bacterial infection

decreased susceptibility to fungal infection

increased susceptibility to parasitic infection

increased susceptibility to Herpesvirales infection

Availability

Mouse Genotype

Lyst^bg-2Btlr/Lyst^bg-2Btlr

Lyst^bg-2J/Lyst^bg-2J

!

Lyst^bg-5Btlr/Lyst^bg-5Btlr

Lyst^bg-6Btlr/Lyst^bg-6Btlr

Lyst^bg-Btlr/Lyst^bg-Btlr

Lyst^bg-grey/Lyst^bg-grey

Lyst^bg-J/Lyst^bg-J

Lyst^bg-Lac/Lyst^bg-Lac

Lyst^bg/Lyst^bg

Lyst^bg-5Btlr/Lyst⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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